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Posted May 22, 2026

Senior Computational Biologist (NYC)

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<p style="min-height:1.5em"><strong>The Role</strong></p><p style="min-height:1.5em">Join our team and help build the world's first biological reasoning model. Work with us to build generative foundational models that decode biological systems across scales - from molecules to organisms - enabling us to predict, understand, and program living systems in ways never before possible.</p><p style="min-height:1.5em">Output is currently in stealth, operated by a team of repeat founders and biotech veterans with multiple exits in AI x Bio, and backed by top-tier VCs including Y Combinator.</p><p style="min-height:1.5em">As a Senior Computational Biologist, you'll work alongside members of our research team and our founders to develop AI systems capable of complex biological reasoning across multiple scales.</p><ul style="min-height:1.5em"><li><p style="min-height:1.5em">You will develop machine learning methods to extend our predictive and generative platform</p></li><li><p style="min-height:1.5em">You will design and execute computational pipelines to validate and prioritized de novo generated molecules using state of the art tools</p></li><li><p style="min-height:1.5em">You will use your deep understanding of biology to design novel therapeutics for hard-to-target proteins with our generative models</p></li><li><p style="min-height:1.5em">You will analyze and integrate large-scale biological datasets</p></li><li><p style="min-height:1.5em">Your work will directly impact the development of our biologically-aware AI platform, transforming the landscape of medicine</p></li></ul><p style="min-height:1.5em">Make a real tangible impact on millions of lives by pushing the boundaries of AI in biology.</p><p style="min-height:1.5em"><strong>Who We're Looking For</strong></p><ul style="min-height:1.5em"><li><p style="min-height:1.5em">You have a PhD in a biological field and strong programming skills in Python</p></li><li><p style="min-height:1.5em">You have experience with computational biology tools such as structure prediction, molecular docking and virtual screening</p></li><li><p style="min-height:1.5em">You have experience working with Protein or Chemical Language Models</p></li><li><p style="min-height:1.5em">You like to work collaboratively in a fast-paced startup environment</p></li><li><p style="min-height:1.5em">You are passionate about using data science to unlock the secrets of biology</p></li><li><p style="min-height:1.5em">You exhibit a proactive approach to problem-solving, thinking beyond the specific task, taking ownership of challenges, and pride in solving them</p></li><li><p style="min-height:1.5em">You have a mature mindset in ambiguous situations, helping to frame questions and seek clarity while making decisions in the face of uncertainty</p></li><li><p style="min-height:1.5em">You have excellent communication skills and can clearly articulate complex technical concepts</p></li></ul><p style="min-height:1.5em"><strong>Bonus Points</strong></p><ul style="min-height:1.5em"><li><p style="min-height:1.5em">You have hands-on experience building AI/ML using PyTorch and Lightning</p></li><li><p style="min-height:1.5em">You have experience with cloud computing platforms like AWS</p></li><li><p style="min-height:1.5em">You have hands-on biology laboratory experience</p></li><li><p style="min-height:1.5em">You have contributed to peer-reviewed publications in computational biology</p></li><li><p style="min-height:1.5em">You have knowledge of machine learning techniques applied to biological data</p></li></ul><p style="min-height:1.5em"></p><h2>Our Values</h2><p style="min-height:1.5em">❤️ <strong>Heart:</strong> We foster a culture of ownership. We are assembling a team of individuals who are passionate and take pride in their contributions.</p><p style="min-height:1.5em">🏆 <strong>Excellence:</strong> We have an unwavering commitment to excellence and continuously challenge ourselves to reach the highest standards.</p><p style="min-height:1.5em">🚀 <strong>Practicality:</strong> We value practicality and results-oriented thinking. We are committed to making a tangible impact on the lives of patients and the broader community.</p><p style="min-height:1.5em">📣 <strong>Honesty:</strong> We place a high value on honesty and directness. We firmly believe in addressing issues as they arise, in an open and transparent manner.</p><p style="min-height:1.5em">🎮 <strong>Fun:</strong> We believe that life is too short to not have fun. Our goal is to create a workplace that is fun, engaging, rewarding and fulfilling.</p><p style="min-height:1.5em"></p><p style="min-height:1.5em"></p><h2>What We Offer</h2><ul style="min-height:1.5em"><li><p style="min-height:1.5em">We encourage new and different ideas, creativity and contrarian thinking</p></li><li><p style="min-height:1.5em">Healthy feedback focused environment to help you strive - leadership will have high expectations, regularly share constructive feedback, support you and help you grow, and welcome receiving feedback and ideas from you</p></li><li><p style="min-height:1.5em">You own your day-to-day management. What we care about is that we all hit our milestones</p></li><li><p style="min-height:1.5em">Competitive salary and equity in a growing, well-funded startup</p></li><li><p style="min-height:1.5em">Excellent medical, dental, and vision coverage</p></li></ul>


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