Note: The job is a remote job and is open to candidates in USA. eClinical Solutions is transforming clinical development with their Clinical Data Cloud, elluminate®, aimed at helping life sciences organizations unlock the value of their data. They are seeking a Principal Full Stack Software Engineer to lead the development of core services and user experiences for their analytics platform, focusing on hands-on development and mentoring within the team.
Responsibilities
- Design, develop, test, and deploy scalable, secure, and highly interactive web applications
- Own and evolve core platform modules, from concept through release and support
- Influence application and system architecture with a focus on performance, reliability, security, and maintainability
- Lead by example through clean, well-tested code, thoughtful design reviews, and pragmatic technical decisions
- Collaborate closely with Product Management, QA, and other engineers throughout the SDLC
- Provide technical mentorship and guidance to other engineers on the team
- Diagnoses and resolves complex production issues across distributed systems
- Ensure solutions meet eClinical Solutions quality standards and applicable industry regulations
- Contribute to technical documentation including design specs, acceptance criteria, and release notes
- Integrating LLMs and AI services into .NET- and Python-based systems
- Designing and implementing AI-assisted workflows, copilots, or intelligent automation features
- Working with agentic AI patterns (e.g., task orchestration, tool-using agents, workflow automation)
- Applying prompt engineering, evaluation techniques, and guardrails to ensure reliability and compliance
- Collaborating with data and platform teams to operationalize AI—not just prototype it
Skills
- Bachelor's or Master's degree in Computer Science or equivalent practical experience
- 10+ years in software design and development using the Microsoft technology stack preferred
- Expert-level proficiency in C#, .NET, and ASP.NET (MVC/Web APIs)
- Strong experience building full-stack web applications (Angular, TypeScript, HTML, CSS)
- Solid understanding of software design principles, patterns, and best practices
- Experience across the full Software Development Lifecycle (Agile preferred)
- Proven ability to work independently while collaborating effectively in a fast-paced environment
- Excellent communication, documentation, and technical leadership skills
- Hands-on experience integrating LLM-based services (e.g., OpenAI, Azure OpenAI, or similar) into applications
- Experience using Python and/or .NET alongside AI/LLM workflows
- Familiarity with agent-based or workflow-driven AI architectures is a strong plus
- Understanding of secure and responsible AI usage in enterprise systems
- Strong SQL expertise (Microsoft SQL Server preferred), including performance tuning
- Experience with microservices, distributed systems, and cloud platforms (AWS preferred)
- Secure development experience, including awareness of common vulnerabilities and mitigations
- Experience with clinical trial data, life sciences, or regulated SaaS environments
- Experience building data visualizations or analytics-driven user experiences
Benefits
- Remote Work
- Top Workplaces Culture Excellence Awards
- Inclusive culture values the contribution that diversity brings
- Opportunities to learn, grow and continuously improve
- Equal opportunity employer that values diversity
Company Overview
eClinical Solutions is a data intelligence hub.it transforms the way clinical data integration, aggregation, and analytics. It is a sub-organization of GI Partners. It was founded in 2006, and is headquartered in Mansfield, Massachusetts, USA, with a workforce of 201-500 employees. Its website is http://www.eclinicalsol.com.Company H1B Sponsorship
eClinical Solutions has a track record of offering H1B sponsorships, with 2 in 2026, 10 in 2025, 7 in 2024, 8 in 2023, 5 in 2022, 5 in 2021. Please note that this does not guarantee sponsorship for this specific role.